The Josie Foundation
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Our mission is fulfilled in part by making grants to organizations that further our cause. The Josie Foundation has made the following grants to date.

December 2016

Amount:  $1,096.93
Recipient: Washington University School of Medicine, Department of Pediatrics, St. Louis, Missouri, in support of research directed by Dr. Joshua B. Rubin. This was our tenth distribution in support of Dr. Rubinís research.

December 2015

Amount:  $1,657.85
Recipient: Washington University School of Medicine, Department of Pediatrics, St. Louis, Missouri, in support of research directed by Dr. Joshua B. Rubin. This was our ninth distribution in support of Dr. Rubinís research.

December 2014

Amount:  $2,820.63
Recipient: Washington University School of Medicine, Department of Pediatrics, St. Louis, Missouri, in support of research directed by Dr. Joshua B. Rubin. This was our eighth distribution in support of Dr. Rubinís innovative and exciting research.

December 2013

Amount:  $9,266.29
Recipient: Washington University School of Medicine, Department of Pediatrics, St. Louis, Missouri, in support of research directed by Dr. Joshua B. Rubin. This was our seventh distribution in support of Dr. Rubinís research. He is making fantastic progress and we are encouraged by the findings he has shown us.

December 2012

Amount:  $8,260.39
Recipient: Washington University School of Medicine, Department of Pediatrics, St. Louis, Missouri, in support of research directed by Dr. Joshua B. Rubin. This was our sixth distribution in support of Dr. Rubinís research.

December 2011

Amount:  $10,335.86
Recipient: Washington University School of Medicine, Department of Pediatrics, St. Louis, Missouri, in support of research directed by Dr. Joshua B. Rubin. This was our fifth distribution in support of Dr. Rubinís research.

December 28 , 2010

Amount:  $10,628.44
Recipient: Washington University School of Medicine, Department of Pediatrics, St. Louis, Missouri, in support of research directed by Dr. Joshua B. Rubin. This was our fourth distribution in support of Dr. Rubinís research.

December 31, 2009

Amount:  $577.18
Recipient: Give Kids the World
This is our third distribution to Give Kids The World. Josie benefited greatly from their kindness and support. From GKTWís website: Give Kids The World is a non-profit organization that exists only to fulfill the wishes of all children with life-threatening illnesses and their families from around the world to experience a memorable, joyful, cost-free visit to the Central Florida attractions, and to enjoy the magic of Give Kids The World Village for as long as there is a need.

November 17, 2009

Amount:  $13,313.45
Recipient: Washington University School of Medicine, Department of Pediatrics, St. Louis, Missouri, in support of research directed by Dr. Joshua B. Rubin. This was our third distribution in support of Dr. Rubinís research. Dr. Rubin and his colleagues are making great progress in gaining an understanding of the causes and possible treatment of pediatric brain cancer. We are proud to be associated with his work.

December 30, 2008

Amount:  $700
Recipient: Give Kids the World
This is our second distribution to Give Kids The World. Josie visited GKTW twice and benefited greatly from their kindness and support. From GKTWís website: Give Kids The World is a non-profit organization that exists only to fulfill the wishes of all children with life-threatening illnesses and their families from around the world to experience a memorable, joyful, cost-free visit to the Central Florida attractions, and to enjoy the magic of Give Kids The World Village for as long as there is a need.

December 10, 2008

Amount:  $13,289.21
Recipient: Washington University School of Medicine, Department of Pediatrics, St. Louis, Missouri, in support of research directed by Dr. Joshua B. Rubin. This was our second distribution in support of Dr. Rubinís research. Dr. Rubin is continuing the research described below and is pursuing other novel theories. We are proud to be associated with Dr. Rubinís work.

December 28, 2007

Amount:  $15,055.90
Recipient: Washington University School of Medicine, Department of Pediatrics, St. Louis, Missouri, in support of research directed by Dr. Joshua B. Rubin.
Brief Description of Dr. Rubin's Research: Dr. Rubin is interested in the biology and treatment of pediatric brain tumors. In his laboratory he and his associates are using the model of normal central nervous system development to help identify molecules that regulate the movements, proliferation and survival of neural progenitor cells. They suspect that these same molecules will influence the infiltrative and metastatic behavior, as well as the proliferation and survival of brain cancer cells. Through this approach, they have identified two molecules, the chemokine CXCL12 (SDF-1a) and its receptor CXCR4 that are critical to normal cerebellar development and whose activation is necessary for growth of medulloblastoma, a neuronal tumor that is the most common brain tumor of childhood and glioblastoma multiforme, a malignant astrocytic tumor. These observations serve as the basis for a wide range of research regarding the role of CXCR4 in tumori-genesis in the CNS and the nature of the intracellular signals that support these functions. These observations also serve as the foundation for designing a clinical trial of CXCR4 antagonist therapy for brain tumors that Dr. Rubin hopes to have underway in the near future. This overlaps with Dr. Rubinís other research interest, which is in the clinical development of novel therapies for brain tumors. In the multidisciplinary Pediatric Brain Tumor Program at St. Louis Children's Hospital, Dr. Rubin and his associates are working to develop and deliver innovative therapies to children with brain tumors.

December 30, 2006

Amount:  $4,358
Recipient: Kennedy Krieger Institute, Baltimore, Maryland.
This was our second distribution in support of a research project titled “Tumor Stem Cell Based Drug Discovery for Adult and Pediatric Glioma” headed up by Dr. John Laterra. See the brief description below.

September 2, 2006

Amount:  $4,770
Recipient: Kennedy Krieger Institute, Baltimore, Maryland.
In support of a research project titled “Tumor Stem Cell Based Drug Discovery for Adult and Pediatric Glioma” headed up by Dr. John Laterra.
Brief Study Description: Pre-clinical models of malignant brain tumors remain important in the identification of anti-cancer compounds. Unfortunately, the cell culture and animal models currently used for drug discovery have deficiencies that limit their ability to predict therapeutic responses in patients. A potentially critical explanation for this deficiency is that past models inadequately address possibility that a small subpopulation of glioma cancer cells with stem-cell-like properties (i.e. glioma cancer stem cells) may generate the bulk of cancer cells within each tumor. This emerging concept predicts that therapies will fail if they do not specifically target the cancer stem cells and stem-cell-driven tumor recurrence. The hypothesis of this 3-year research program is that stem-cell-like cancer cells in glioma are a necessary and specific primary target for therapeutic intervention. We propose to pursue this hypothesis, looking at both adult and pediatric gliomas, with a new collaborative network of scientists and clinicians from four academic institutions within the United States and Italy who are experts in the fields of basic stem cell biology, cancer biology, molecular genetics, neuropathology, neuro-oncology, neurosurgery, neuroradiology, experimental therapeutics, and clinical trial design.

June 11, 2006

Amount:  $4,770
Recipient: The Dream Factory of St. Louis, Friends of Kids With Cancer and Give Kids the World
Each of these organizations has touched our lives, as well as countless others, in their efforts to help children with life-threatening diseases.